CD not only affects the intestine, it is a systemic disease that can cause lesions to the skin, joints, brain and other organs. The onset of symptoms is generally gradual and can appear months or even years after the introduction of gluten in the diet.
The main gastrointestinal symptoms are diarrhea, flatulence, weight loss, abdominal bloating, mood swings, etc.
However, there are also extra-intestinal symptoms that affect the mouth, skin, nervous system, joints, liver, endocrine system, female reproductive system, and blood; the most common being iron deficiency anemia4.
Therefore, CD appears in the spectrum of a wide range of symptoms, which makes early diagnosis of this disease more complicated.