Liver transplantation and de novo post-transplant hepatitis
Recently, a new form of liver transplant rejection was described: de novo post-transplant hepatitis. This causes a disease that is clinically difficult to distinguish over other hepatitis diseases and responds to immunosuppressive treatment19,20.
Diagnosis is very difficult because it requires serological, histological, radiological and molecular biology data. De novo post-transplant hepatitis has been shown to be caused by an allo-immune response against an antigen, glutathione S-transferase theta 1 (GSTT1) originating in the graft21–23.
Patients with de novo post-transplant hepatitis developed high levels of antibodies directed against GSTT1. These studies show GSTT1 incompatibility as a fundamental element in the development of this type of hepatitis, and propose GSTT1 antibodies as new markers of liver transplant rejection. Furthermore, a correlation with kidney transplants or blood transfusions has been shown.
Anti-GSTT1 antibody detection kit
An anti-GSTT1 ELISA kit is an immunosorbent assay that detects anti-GSTT1 in human sera.
Kit REF. Format Anti-GSTT1 KT-4723 96 wells
Enzyme-linked immunosorbent (ELISA) assay for detection of anti-GSTT1 antibodies in sera (RUO-Research use only)